TY - JOUR AU - Wan, Minying PY - 2017/12/01 Y2 - 2024/03/28 TI - Serous Levels of Inflammatory Cytokines Are Predictive of Unstable Angina and Non-STsegment Elevation Myocardial Infarction JF - American Journal of Translational Medicine JA - Am J Transl Med VL - 1 IS - 4 SE - Articles DO - UR - https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/889 SP - 249-261 AB - <p>BACKGROUND: Although immune-inflammatory responses are associated with cardiovascular diseases, particularly acute coronary syndrome (ACS), predictive inflammatory markers of ACS severity are unknown. METHODS: ACS (specifically unstable angina and non-ST-segment elevation myocardial infarction) patients (306 subjects) undergoing coronary angiography for chest pain evaluation were enrolled in this study. The severity of their coronary lesions was assessed using the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score. Enzyme-linked immunosorbent assays (ELISAs) were used to detect serum levels of interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and IL-2 receptor (IL-2R). A generalized linear model was employed to describe the association between ACS severity and inflammatory cytokine levels. RESULTS: Increases in IL-2R, hs-CRP, and IL-6, but not TNF-α, were positively associated (p &lt; 0.05) with SYNTAX score. Hs-CRP levels were significantly higher (p &lt; 0.05) in the middle and high SYNTAX score groups than in the low SYNTAX score group. In the generalized linear model, levels of hs-CRP and IL-6 were associated with 4.3 % and 11.0 % increases in SYNTAX score, respectively. There was a significant association between SYNTAX score and hs-CRP, IL-6, and TNF-α in participants with either diabetes or hypertension, while increased IL-2R levels were only associated with SYNTAX score in participants with both diabetes and hypertension. CONCLUSION: These results suggest that hs-CRP, IL-6, and IL-2R could function as biomarkers indicative of an immune-inflammatory response in ACS patients. Inflammatory cytokine activity detectable in peripheral blood may be useful for identifying subjects with more severe lesion conditions. Detection of these indicators could predict the severity of coronary artery lesions and help to direct clinical decisions and treatment. (Am. J. Transl. Med. 2017. 1:249-261)</p> ER -