Local microenvironment regulates the metabolic characteristics of transferred adipose tissue
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How to Cite

Mao, X. . (2017). Local microenvironment regulates the metabolic characteristics of transferred adipose tissue. American Journal of Translational Medicine, 1(4), 237–248. Retrieved from https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/888

Abstract

Different types of adipose tissues play different roles in the body metabolism. We studied the metabolic effects of different adipose tissues in obese mice model. High-fat diet induced obese mice were divided into four groups: A) autologous white adipose graft to brown adipose region; B) autologous brown adipose graft to white adipose region; C) autologous white adipose graft to brown adipose sham operation group; D) autologous brown adipose graft to white adipose sham operation group. Serum lipids level and adipose metabolic related genes expression were detected. Before the treatment, the high fat diet mice developed obese related hyperglycemia and dyslipidemia. After the treatment, all treatment groups showed decrease in weights and blood glucose levels, but only the white to brown group mice weight and blood glucose level decrease to normal within 2 months. Moreover, the comprehensive monitoring showed that white to brown group mice had lower activity but higher heat production compared to other groups. The leptin and adiponectin levels were significantly increased in white to brown group in 3 months’ post treatment. Generally, our experiment provides that autologous white adipose tissue transfer to brown adipose tissue can cause adipose tissue function alteration and can reverse high fat diet mice metabolic malfunction (Am. J. Transl. Med. 2017. 1:237-248)

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