Abstract
Breast cancer is a malignant tumor with a high incidence among women globally. The occurrence and development of breast cancer are associated with genetic and environmental factors, which can induce gene variation. Super enhancers comprise a series of elements that enhance gene transcription, such as master transcription factors, RNA polymerase II, coactivators, histone modification, topology-related domains, and enhancer RNA. They are closely associated with pathogenesis and pathological processes, such as tumor metastasis, immune escape, and drug resistance, as well as the expression of tumor-related genes. By reviewing the relevant literature, this article aims to deepen the understanding of super enhancers, their pathological significance and biological potential in breast cancer. (Am J Transl Med 2020. 4:40-54).