Roles of Super enhancers in Breast cancer
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Keywords

Super enhancer, breast cancer, transcriptional regulation, PD-L1

How to Cite

Shu, L. (2020). Roles of Super enhancers in Breast cancer. American Journal of Translational Medicine, 4(2), 40–54. Retrieved from https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/612

Abstract

Breast cancer is a malignant tumor with a high incidence among women globally. The occurrence and development of breast cancer are associated with genetic and environmental factors, which can induce gene variation. Super enhancers comprise a series of elements that enhance gene transcription, such as master transcription factors, RNA polymerase II, coactivators, histone modification, topology-related domains, and enhancer RNA. They are closely associated with pathogenesis and pathological processes, such as tumor metastasis, immune escape, and drug resistance, as well as the expression of tumor-related genes. By reviewing the relevant literature, this article aims to deepen the understanding of super enhancers, their pathological significance and biological potential in breast cancer. (Am J Transl Med 2020. 4:40-54).

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