A longitudinal rs-fMRI study of the effect of diabetic optic neuropathy on small-world topology
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Keywords

Magnetic resonance imaging
Diabetic optic neuropathy
Endemic reticulation efficaciousness
Clustering coefficients

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How to Cite

Hu, J., Shao, Y., Yu, Y., Huang, H., & Chen, X. (2023). A longitudinal rs-fMRI study of the effect of diabetic optic neuropathy on small-world topology: Small-world topology study of diabetic optic neuropathy. American Journal of Translational Medicine, 7(4), 362–371. Retrieved from https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/2947

Abstract

PURPOSE: We evaluated imaging information from patients with diabetic optic neuropathy (DON) to determine whether their brain structure networks had small-world properties and studied their changes in related feature parameters. METHODS: The study included 23 patients with DON and 23 healthy controls (HCs). Participants underwent MRI scans, and the resulting data were analyzed using a graph theory approach to evaluate changes in brain regions and small-world topology. RESULTS: Both patients with DON and HCs exhibited normalized clustering coefficients (γ) clearly > 1, endemic reticulation efficaciousness (Eloc) of approximately 1, and small-worldness (σ) > 1, demonstrating that both groups exhibited typical small-world topology; however, compared to HCs, patients with DON showed substantially decreased γ, σ, and Eloc values. CONCLUSIONS: Patients with DON showed typical small-world topology, but there were abnormal changes in the overall and local attributes of the networks, and the abnormal changes in the small-world network attributes of DON patients might cause cognitive dysfunction, such as problems with information integration and executive control.

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