Caspases: Possible future targets for subarachnoid hemorrhage research
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Jin, T., Dong, S., Han, M., Niu, H., & Liu, A. (2023). Caspases: Possible future targets for subarachnoid hemorrhage research. American Journal of Translational Medicine, 7(3), 171–178. Retrieved from https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/2831

Abstract

Subarachnoid hemorrhage (SAH) is a serious cerebrovascular event with high morbidity and mortality rates that poses a major public health challenge. The disease mechanisms underlying a poor prognosis in SAH are complex and multifactorial, and an increasing number of studies are now focusing on this topic. Caspases are a conserved family of cysteine-aspartic proteases that play a crucial role in programmed cell death and inflammation. In recent years, some studies have shown that caspases play a key role in SAH; they are considered an extremely promising target. Here, we review the roles of various caspase family members in SAH and provide a perspective to inform future research on caspases.

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